What are the different levels of severity of Proteus Syndrome and how do those levels of severity of Proteus Syndrome affect the patient?

by Filipe
(Houston,TX)

I would like to know about the different levels of severity of Proteus Syndrome and how it affects the patient. Why do these levels of severity occur?

Related: Karyotype and Genetic Diseases.

Answers for What are the different levels of severity of Proteus Syndrome and how do those levels of severity of Proteus Syndrome affect the patient?

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Answer to Question
by: Myra Burt

Unlike inherited disease-causing mutations, the gene variant that triggers Proteus occurs spontaneously in each affected individual during embryonic development. The severity of the disease depends on the timing during embryonic development that the genetic mistake occurs in a single cell and in which part of the developing organism. Only the cells that descend from the cell with the original AKT1 gene mutation display the hallmarks of the disease, leaving the individual with a mixture of normal and mutated cells.

Proteus Syndrome Levels of Severity
by: Anonymous

There are many different levels of severity for certain symptoms pertaining to this disorder. The severity of the symptoms can range from the size of the overgrowth of the limbs, bones, and organs, or if they have other diseases from the genetic disorder such as Scoliosis or Strabismus. All of the levels of severity depend on the mutation of that patient and what proteins are produced from that mutation. These levels of severity can affect the patient in a variety of ways by either shortening their life, receiving life threatening conditions, or difficulty in their everyday activities. Either way, it all depends on the how good or bad the mutation was in that patients genetics.

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