Why the mutagenesis rate of auxotrophs by mutagens for secondary metabolites is higher than in prototrophic bacteria?

by Hasan

In many industrial microbiology texts, it has written that the mutagenesis rate of secondary metabolites in auxotrophs is 10-2 to 10-1 per generation and per gene and in prototrophic bacteria is 10-10 to 10-5 (normally 10-7 to 10-6). I can't find its reasons in text books or articles.

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